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Dental ankylosis

1 associated gene
6 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

Brachydactyly type E

2 OMIM references -
2 associated genes
8 signs/symptoms

Dental ankylosis

Brachydactyly type E

PTH1R	(UniProt - OMIM)		HOXD13	(UniProt - OMIM)
			PTHLH	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	PTH1R	(0.85)	PTHLH

Citations in the biomedical literature:

Dental ankylosis		Brachydactyly type E
	Synonym(s): - Ankylosis of teeth		Synonym(s): (no synonyms)

	Classification (Orphanet): - Rare genetic disease - Rare odontologic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease

	Classification (ICD10): - Diseases of the digestive system -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: (no data available)		Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant

	External references: No OMIM references 1 MeSH reference: D020254		External references: 2 OMIM references - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance

Dental ankylosis		Brachydactyly type E
	Very frequent - Anodontia / oligodontia / hypodontia Frequent - Abnormal dentition / dental position / implantation / unerupted / dental ankylosis - Enamel anomaly Occasional - Clinodactyly of fifth finger - Prognathism / prognathia		Very frequent - Metacarpal anomalies / Archibald's sign Frequent - Hyperextensible joints / articular hyperlaxity - Short stature / dwarfism / nanism - Terminal / third phalangeal bone of fingers hypoplasia Occasional - Frontal bossing / prominent forehead - Macrocephaly / macrocrania / megalocephaly / megacephaly - Upper limb asymmetry / hemiatrophy / hemihypertrophy